The Door That Chemistry Opens: Psychedelics and the Neuroscience of Mystical Experience
She had already asked me everything a patient asks about a new cancer diagnosis — staging, prognosis, what comes next. Then, just as her hand was on the door, she turned back. "Doctor," she said quietly, "I read that a single dose of something can take away the fear of dying. Is that real? Could someone like me try it?" I did not have a prescription to offer her. But the question stayed with me, because it was really two questions folded into one: a question about a molecule, and a question about what waits on the other side of fear. Neuroscience has begun to answer the first. The second is older than any laboratory. In 2016, research teams at Johns Hopkins and New York University published, almost simultaneously, trials in which patients facing life-threatening cancer were given a single carefully supervised dose of psilocybin, the active compound in certain mushrooms. The results were striking: depression and anxiety dropped sharply, the dread of death eased...